Sinisa Pajevic

e-mail: pajevic@nih.gov
Mathematical and Statistical Computing Lab
Office of Intramural Research
Center for Information Technology
National Institutes of Health
Tel: (301) 435-5049


General Information

Research Interests: mathematical and computer modeling, neuroscience, machine learning, statistical analysis


Research Projects

Models of Myelin and Delay Plasticity
Conducting theoretical and computational studies of the effect that myelin and delay plasticity have on the functioning and stability of complex systems, and investigating the biological mechanisms and the role of glial cells in myelin plasticity. (with R. Douglas Fields, and Peter J. Basser, NICHD).

Imaging and Measuring Brain Latency
Developing a pipeline for measuring brain latency in vivo using four different imaging modalities: diffusion MRI, electroencephalography (EEG), magnetoencephalography (MEG) and transcranial magnetic stimulation (TMS) data. Co-principal investigator on "BRAIN Initiative" grant with Peter J. Basser (NICHD), Richard Coppola (NIMH), Mark Hallett (NINDS), R. Douglas Fields, (NICHD).

Machine Learing Approaches in Biology and Medicine
A number of projects involving patient outcome predictions, estimating the connectivity of C. elegans worm from cellular gene expression patterns, and developing computational methods for automated segmentation of distinct neuroanatomical regions in larval zebrafish using large transgene expression datasets. (with James D. Malley, CIT, and Harold A. Burgess, NICHD).

Analysis of the In-Vitro Neuronal Multi-electrode Recordings
Analyzing multi-electrode recordings of the in-vitro neural network preparations. Involves (i) finding the attractors of the network using clustering methods (ii) analysis and simulations of the corresponding network topology (with Dietmar Plenz, NIMH).

Diffusion Tensor Imaging (DTI)
Involves (i) Parametric and non-parametric statistical anlysis of the DTI data; (ii) color representation of DTI data; (iii) Automated segmentation of the relevant anatomical structures of the brain using fiber tractography. (with Peter Basser, NICHD and Carlo Pierpaoli, NINDS) (iv) B-spline Continuous Approximation of DT-MRI data ( Download BCADT shared library for Linux)

Recent Publications (OIR Publications List)


Related Sites

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Contact

Sinisa Pajevic
Mathematical and Statistical Computing Laboratory
Office of Intramural Research
Center for Information Technology
National Institutes of Health
Bldg 12A, Rm. 2001
Bethesda, MD 20892-5620
Tel: (301) 435-5049
Fax: (301) 402-4544
e-mail: pajevic@nih.gov



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Last updated: May 15, 2003


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