Jennifer J. Barb, Ph.D.

e-mail: barbj@mail.nih.gov

Tel: (301) 435-9232

Education

Ph.D. Bioinformatics, George Mason University, May 2009
M.S. Biotechnology, Johns Hopkins University, 2003
B.S. Computer and Information Science, University of Maryland, University College, 2001
B.S. Biological Sciences, University of Maryland, Baltimore County, 1999

Interests: Statistical analysis of Affymetrix gene chip microarrays, statistical analysis of Next-Gen sequencing data, visualization and graphical tools of bioinformatics data, gene-chip annotation procedures.

CV

Research Projects

Development of statistical software for the analysis of gene expression microarray data.

Development of statistical filtering and analysis techniques for exon microarray data.

Development of annotation procedures for the Affymetrix exon array.

Recent Publications (DCB Publications List)

• Hernandez-Novoa B, Bishop L, Logun C, Munson PJ, Elnekave E, Rangel ZG, Barb J, Danner RL, Kovacs JA., Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice. J Leukoc Biol. 2008 May 8. in press

• Woszczek G, Chen LY, Nagineni S, Kern S, Barb J, Munson PJ, Logun C, Danner RL, Shelhamer JH., Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. J Allergy Clin Immunol. 2008 Jan;121(1):215-221

• Elshal MF, Khan SS, Raghavachari N, Takahashi Y, Barb J, Bailey JJ, Munson PJ, Solomon MA, Danner RL, McCoy JP Jr., A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile. BMC Immunol. 2007 Nov 13;8:29.

• Oliveira JB, Bidère N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM, Dale J, Straus SE, Fleisher TA, Lenardo MJ., NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8953-8.

• Cleary S, Phillips JK, Huynh TT, Pacak K, Elkahloun AG, Barb J, Worrell RA, Goldstein DS, Eisenhofer G., Neuropeptide Y expression in phaeochromocytomas: relative absence in tumours from patients with von Hippel-Lindau syndrome. J Endocrinol. 2007 May;193(2):225-33.

• Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Kato G, Munson PJ, Morris SM Jr, Gladwin MT., Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation. 2007 Mar 27; 115(12):1551-62. Epub 2007 Mar 12.

• Barb JJ, Munson PJ: The MSCL Analyst's Toolbox: A powerful analysis package for Microarray Data. Functional Genomics and Critical Illness and Injury: Surviving Stress, poster, Bethesda, MD, November 13-14, 2006

• Barb JJ, Munson PJ: The MSCL Analyst's Toolbox: A powerful analysis package for Microarray Data. NIH Research Festival 2006, poster, Bethesda, MD October 2006

• Barb JJ, Munson PJ: The MSCL Analyst's Toolbox: A powerful analysis package for Microarray Data. Microarray Data Analysis and Interpretation, poster, Washington DC, April 23-25, 2006

• Brouwers FM, Elkahloun AG, Munson PJ, Eisenhofer G, Barb J, Linehan WM, Lenders JW, DE Krijger R, Mannelli M, Udelsman R, Ocal IT, Shulkin BL, Bornstein SR, Breza J, Ksinantova L, Pacak K: Gene expression profiling of benign and malignant pheochromocytoma. Ann N Y Acad Sci. 2006 Aug;1073:541-56

• Wang S, Zhang J, Theel S, Barb JJ, Munson PJ, Danner RL, Nitric oxide activation of Erk1/2 regulates the stability and translation of mRNA transcripts containing CU-rich elements. Nucleic Acids Res. 2006 Jun 6;34(10):3044-56. Print 2006.

• Talwar S, Munson PJ, Barb JJ, Fiuza C, Cintron AP, Logun C, Tropea J, Khan S, Reda D, Shelhamer JH, Danner RL, Suffredini AF, Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans. Physiol Genomics. 2006 Apr 13;25(2):203-15. Epub 2006 Jan 10.

• Cui X, Zhang J, Ma P, Myers DE, Goldberg IG, Sittler KJ, Barb JJ, Munson PJ, Cintron Adel P, McCoy JP, Wang S, Danner RL, cGMP-independent nitric oxide signaling and regulation of the cell cycle. BMC Genomics. 2005 Nov 3;6:151.

• Pawliczak R, Logun C, Madara P, Barb J, Suffredini AF, Munson PJ, Danner RL, Shelhamer JH, Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone. Physiol Genomics. 2005 Sep 21;23(1):28-45. Epub 2005 Jun 28.

• Barb JJ, Schindel H, Munson PJ: GO-SCAN: analysis and visualization of Gene Ontology annotations, Gene Ontology Significant Collection of Annotations. NIH Research Festival 2004, poster, Bethesda, MD. September 2004.

• Jison ML, Munson PJ, Barb JJ, Suffredini AF, Talwar S, Logun C, Raghavachari N, Beigel JH, Shelhamer JH, Danner RL, and Gladwin ML: Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic and inflammatory stress of sickle cell disease. Blood, July 2004.

Contact

Jennifer J. Barb

National Institutes of Health

12 South Drive

Building 12A, Room 2001C

Bethesda, MD 20892-5620

Tel: (301) 435-9232

Fax: (301) 402-4544

e-mail: barbj@mail.nih.gov

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Last updated: October 2004

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